Conducting all animal experiments on mice, rats, rabbits, hamsters, monkeys, piglets, zebrafish, worms, flies

Development of animal models for various conditions, including multiple sclerosis (MS), type 1 and type 2 diabetes, anxiety, depression, obesity, rheumatoid arthritis, breast cancer, colon cancer, thyroid cancer, epilepsy, Alzheimer's disease, Parkinson's disease, drug and alcohol addiction, autism, pain disorders, viral and bacterial infections, liver fibrosis, fatty liver disease, kidney failure, azoospermia, gut microbiome alterations, ulcers, atherosclerosis, and osteoporosis, among others.

Conducting experiments on pregnant animals, infants, children, adolescents, adults, and the elderly.

Evaluation of Pharmacological Trials, Behavioral Interventions, and Exercise-Based Therapies

Assessing behaviors related to sexual activity, stress response, anxiety, depression, memory and learning capacities, aggression, motor skills, and maternal care.

Administering various drugs into distinct regions of the body (muscular, peritoneal, subcutaneous) and specific areas of the brain, guided by the Paxinus Atlas.

Preclinical toxicology studies are conducted before phase I trials of novel therapeutics to determine a safe starting dose for clinical use and to identify potential human toxicities.

The various cytology methods are most effective when all four stages of the cell cycle must be identified.

Microbiological assessment of the health status of laboratory rats and mice involves evaluating representative sample groups from specific colonies against a defined list of disease-causing agents. This process aims to determine the overall health status of the source colony.

A repeated and single-dose toxicity study will be conducted to evaluate the toxicity of the selected drugs and vaccine. In this study, selected animals will receive gavage or injection at predetermined intervals and will be compared to a control group.

Key assessments will include morbidity/mortality rates, clinical examinations, body weight measurements, food consumption, and tissue pathology evaluations. Organs and tissues (including the brain, lungs, kidneys, heart, liver, adrenal glands, male and female reproductive systems, spleen, small intestine, and colon) will be weighed and examined histopathologically.

Tissues from all groups will be assessed for necrosis, apoptosis, and inflammation. Individual and overall tissue damage scores will be calculated and analyzed using GraphPad software.

Biochemical studies will assess the levels of key blood factors, liver enzymes, seroconversion, and serological markers.

All tests concerning the genetic material of live attenuated vaccines—including viral shedding, residual genetic material in tissues, genetic alterations in animals, and genotoxicity—will be conducted at this stage.

Regulatory Approaches to Pharmaceuticals by the Food and Drug Administrations of Iran, the United States, and Europe

Writing Scientific Reports and Articles in English